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pentobarbital decreases amounts of ponatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Steer clear of Except if the coadministration outweighs the possible threat of ponatinib underexposure; observe for signs of diminished efficacy.pentobarbital will lessen the level or influence of doxorubicin liposom